What is the 2-Phenylacetamide?

2-Phenylacetamide is White krystalline powder., while it's Molecular Formula is C8H9NO. White krystalline powder. 2-Phenylacetamide is used as a pharmaceutical intermediate in the production of penicillin G and phenobarbital, etc. It is also used in organic synthesis.

What is the CAS number for 2-Phenylacetamide?

The CAS number of 2-Phenylacetamide is 103-81-1.

What is 2-Phenylacetamide (103-81-1) used for?

2-Phenylacetamide, also known as acetanilide, is a monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. It is a white flaky crystalline compound with chemical properties that include solubility in hot water, ethanol, and slight solubility in cold water, ether, and benzene. It has a role as a mouse metabolite and is derived from phenylacetic acid.InChI:InChI=1/C8H9NO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)

What is the 2-Phenylacetamide?

2-Phenylacetamide is White krystalline powder., while it's Molecular Formula is C8H9NO. White krystalline powder. 2-Phenylacetamide is used as a pharmaceutical intermediate in the production of penicillin G and phenobarbital, etc. It is also used in organic synthesis.

What is the CAS number for 2-Phenylacetamide?

The CAS number of 2-Phenylacetamide is 103-81-1.

What is 2-Phenylacetamide (103-81-1) used for?

2-Phenylacetamide, also known as acetanilide, is a monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. It is a white flaky crystalline compound with chemical properties that include solubility in hot water, ethanol, and slight solubility in cold water, ether, and benzene. It has a role as a mouse metabolite and is derived from phenylacetic acid.InChI:InChI=1/C8H9NO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)

2-Phenylacetamide

Basic information

Product Name:2-Phenylacetamide
CasNo.:103-81-1
MF:C₈H₉NO

Physical and Chemical Properties

Purity:99%
Melting Point:156 °C
Appearance:White krystalline powder.

Inquiry

Product Details

CasNo： 103-81-1

MF： C₈H₉NO

Appearance： White krystalline powder.

Purity 99% Min 2-Phenylacetamide 103-81-1 Spot Supply with Safe Transportation

Molecular Formula:C8H9NO
Molecular Weight:135.166
Appearance/Colour:White krystalline powder.
Vapor Pressure:0.000537mmHg at 25°C
Melting Point:156 °C
Refractive Index:1.552
Boiling Point:312.2 °C at 760 mmHg
PKA:16.21±0.40(Predicted)
Flash Point:142.6 °C
PSA：43.09000
Density:1.098 g/cm³
LogP:1.41470

2-Phenylacetamide(Cas 103-81-1) Usage

Description	2-phenylacetamide is a monocarboxylic acid amide and an organic compound that is a derivative of phenylacetic acid. It is also known as alpha-toluamide or benzeneacetamide. 2-Phenylacetamide (2-PA, C8H9NO, CAS No. 103-81-1) is a useful chemical as an intermediate in the synthesis of pharmaceuticals, such as the sedative drug phenobarbital. Additionally, it could be adopted as a precursor to prepare other downstream products, e.g. phenylacetic acid, isocyanatomethylbenzene and D-phenylalanine.
Synthesis and Preparation	Synthesis of 2-phenylacetamide: Add concentrated hydrochloric acid to phenylacetonitrile, stir to dissolve, and react at 50°C for half an hour. Then slowly add water under cooling to separate out crystals, filter after cooling, wash with ice water to obtain crude product. The crude product was washed with sodium carbonate solution, then washed with ice water, and dried to obtain purer phenylacetamide. DEMEI ELECTRONIC COMMERCE FIRM was established in 2024 and is located in Yiwu, Zhejiang Province. Although it was established not long ago, it has more than ten years of industry experience. The affiliated factory covers an area of 7,000 square meters.
Biological Activity	2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells.
Safety Profile	Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.

InChI:InChI=1/C8H9NO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)

103-81-1 Relevant articles

Solubility behavior of 2-phenylacetamide in sixteen pure solvents and dissolution properties of solution

Yajun Li a , Kui Wu b , Lei Liang a

, Journal of Molecular Liquids Volume 291 , 1 October 2019, 111264

The results demonstrate that the dissolution of 2-phenylacetamide is a spontaneous and entropy-driven process in the selected solvents. The solubility data, correlation models and derived dissolution properties would promote the development of the separation and reaction of 2-phenylacetamide in industry.

Choline chloride based eutectic solvent: An efficient and reusable solvent system for the synthesis of primary amides from aldehydes and from nitriles

Patil, Umakant B.,Singh, Abhilash S.,Nagarkar, Jayashree M.

, p. 1102 - 1106 (2014)

Choline chloride: a 2ZnCl2 based deep eu...

Selective hydration of nitriles to amides promoted by an Os-NHC catalyst: Formation and X-ray characterization of κ2-amidate intermediates

Buil, Maria L.,Cadierno, Victorio,Esteruelas, Miguel A.,Gimeno, Jose,Herrero, Juana,Izquierdo, Susana,Onate, Enrique

, p. 6861 - 6867 (2012)

The complex [Os(η6-p-cymene)(OH)IPr]OTf ...

Silica-supported 2,4,6-trichloro-1,3,5-triazine as an efficient reagent for direct conversion of carboxylic acids to amides under solvent-free conditions

Khalafi-Nezhad, Ali,Zare, Abdolkarim,Parhami, Abolfath,Rad, Mohammad Navid Soltani,Nejabat, Gholam Reza

, p. 657 - 666 (2007)

A very simple and efficient solvent-free...

Efficient method for the direct preparation of amides from carboxylic acids using tosyl chloride under solvent-free conditions

Khalafi-Nezhad, Ali,Parhami, Abolfath,Soltani Rad, Mohammad Navid,Zarea, Abdolkarim

, p. 6879 - 6882 (2005)

A simple, clean and highly efficient sol...

2-Diphenylphosphanyl-4-pyridyl(dimethyl)amine as an effective ligand for the ruthenium(II) complex catalyzed homogeneous hydration of nitriles under neutral conditions

Muranaka, Makoto,Hyodo, Isao,Okumura, Wataru,Oshiki, Toshiyuki

, p. 552 - 555 (2011)

New homogeneous catalyst comprised of [R...

Chemoselective hydration of nitriles to amides using hydrated ionic liquid (IL) tetrabutylammonium hydroxide (TBAH) as a green catalyst

Veisi, Hojat,Maleki, Behrooz,Hamelian, Mona,Ashrafi, Samaneh Sedigh

, p. 6365 - 6371 (2015)

A transition metal-free process, catalyz...

HYDROLYSIS IN THE ABSENCE OF BULK WATER 1. CHEMOSELECTIVE HYDROLYSIS OF AMIDES USING TETRAHALOPHTALIC ANHYDRIDES

Eaton, Jefferson T.,Rounds, William D.,Urbanowicz, John H.,Gribble, Gordon W.

, p. 6553 - 6556 (1988)

The reaction of primary and secondary am...

Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: Synthesis of primary amides

Kamble, Rohit B.,Mane, Kishor D.,Rupanawar, Bapurao D.,Korekar, Pranjal,Sudalai,Suryavanshi, Gurunath

, p. 724 - 728 (2019)

A new heterogeneous catalytic system (Ti...

2-Phenylacetamide Isolated from the Seeds of Lepidium apetalum and Its Estrogen-Like Effects In Vitro and In Vivo

Mengnan Zeng 1,2,†,Meng Li 1,2,†,Miao Li 1,2,Beibei Zhang 1,2,Benke Li 1,2,Li Zhang 1,2,Weisheng Feng 1,2 andXiaoke Zheng 1,2,*

, p. 895 - 899 (2013)

In our preliminary study, we found that several Chinese herbal medicines showed estrogen-like effects, including LA. Then, we isolated the main compounds from LA and obtained 2-phenylacetamide (PA) [12] and some other compounds and examined their estrogen-like activities. However, the estrogen-like effects of LA and PA have not yet been reported. Therefore, in this study, we evaluated the estrogen-like effects of LA and PA in vitro and in vivo, and explored the potential mechanisms.

Direct catalytic formation of primary and tertiary amides from non-activated carboxylic acids, employing carbamates as amine source

Tinnis, Fredrik,Lundberg, Helena,Adolfsson, Hans

, p. 2531 - 2536 (2012)

The operationally simple titanium(IV)- o...

Synthesis of and catalytic nitrile hydration by a cationic tris(μ-hydroxo)diruthenium(II) complex having PMe3ligands

Kiyota, Sayori,Kobori, Takako,Soeta, Hirofumi,Ichikawa, You-ichi,Komine, Nobuyuki,Komiya, Sanshiro,Hirano, Masafumi

, p. 3 - 10 (2016)

While phenyl vinyl ether does not react ...

103-81-1 Upstream products

186581-53-3
diazomethane
98-88-4
benzoyl chloride
100-42-5
styrene
103-82-2
phenylacetic acid

103-81-1 Downstream products

6319-63-7
phenyl-acetic acid xanthen-9-ylamide
109939-51-7
N,N'-bis-phenylacetyl-furfurylidenediamine
95275-76-6
5-benzyl-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
22442-73-5
N,N'-((4-nitrophenyl)methylene)bis(2-phenylacetamide)