2-(Di-tert-butylphosphino)-2'-methyl-1,1'-biphenyl
CAS: 255837-19-5
Category: Organic Pharmaceutical Intermediates
| Purity | Catalyst Grade ≥98%; Research Grade ≥99%; HPLC Grade ≥99% |
| Molecular Formula | C21H29P |
| Molecular Weight | 312.43 |
| Appearance | White to off-white crystalline powder |
| Packaging | 1 g, 5 g, 10 g, 25 g, 100 g amber glass bottle or fluorinated HDPE bottle; customized bulk packaging available |
| Testing Indicators | Appearance — Visual inspection; Identification — ¹H NMR, ¹³C NMR and ³¹P NMR; Molecular weight — HRMS or LC-MS; Purity — HPLC (UV) and/or GC; Phosphine oxide impurity — ³¹P NMR or HPLC; Water content — Karl Fischer titration (GB/T 6283); Residual solvents — GC (ICH Q3C); Melting point — Capillary melting point determination; Elemental analysis — CHN elemental analysis. |
| Storage Notes | Store tightly sealed under an inert atmosphere (nitrogen or argon) in a cool, dry, well-ventilated place. Protect from moisture, oxygen, heat, and direct sunlight. Recommended storage temperature is 2–8°C. Minimize exposure to air during weighing and transfer. Reseal containers immediately after use. |
| Lead Time | 10 days |
A bulky, highly electron-rich biaryl monophosphine ligand widely used in transition-metal catalysis. Commonly employed as a ligand for palladium-catalyzed Buchwald-Hartwig amination, Suzuki-Miyaura, Negishi, Kumada, Sonogashira, and Stille cross-coupling reactions. Frequently utilized in catalyst screening, pharmaceutical process development, agrochemical synthesis, and fine chemical manufacturing due to its excellent activity toward sterically hindered substrates.