2-(Dicyclohexylphosphino)-2'-methoxybiphenyl
CAS: 255835-82-6
Category: Organic Pharmaceutical Intermediates
| Purity | Research Grade ≥97%; Catalyst Grade ≥98%; High-Purity Grade ≥99% |
| Molecular Formula | C25H33OP |
| Molecular Weight | 380.50 |
| Appearance | White to pale yellow crystalline powder |
| Packaging | 1 g, 5 g, 10 g, 25 g, 100 g amber glass bottle or aluminum foil bag under nitrogen or argon |
| Testing Indicators | Appearance — Visual inspection; Identification — ¹H NMR, ¹³C NMR and ³¹P NMR; Molecular weight confirmation — HRMS or LC-MS; Purity — HPLC or GC; Phosphorus identification — ³¹P NMR; Water content — Karl Fischer titration (GB/T 6283); Residual solvents — GC (ICH Q3C); Melting point — Capillary melting point apparatus; Elemental analysis — CHN; Heavy metals — ICP-MS. |
| Storage Notes | Store tightly sealed under nitrogen or argon in a cool, dry, well-ventilated location. Protect from moisture, oxygen, direct sunlight, and sources of heat. Refrigerated storage at 2-8°C under inert atmosphere is recommended for long-term preservation. Avoid repeated exposure to air during sampling. |
| Lead Time | 10 days |
A bulky electron-rich monophosphine ligand extensively used in palladium-catalyzed cross-coupling chemistry. Frequently applied in Buchwald-Hartwig amination, Suzuki-Miyaura, Negishi, Kumada, Sonogashira, and Stille coupling reactions. It serves as a high-performance ligand for catalyst development and the synthesis of pharmaceutical intermediates, agrochemicals, and fine chemicals.