Nilotinib (monohydrochloride monohydrate)
CAS: 923288-90-8
Category: Kinase Inhibitors
| Purity | Pharmaceutical Grade, High-Purity Research Standard (≥98%). |
| Molecular Formula | C28H25ClF3N7O2 |
| Molecular Weight | 583.99 |
| Appearance | White to slightly yellowish powder |
| Packaging | 25 kg/fiber drum, 1 kg/aluminum foil bag. |
| Testing Indicators | Appearance — Visual inspection; Identification — IR, Chloride test; Purity — Gradient RP-HPLC; Water content — Karl Fischer titration; Chloride — Argentometric titration; Heavy metals — ICP-MS; Residual solvents — HS-GC; Microbial limits — Filtration; Polymorphic form — XRPD. |
| Storage Notes | Stored in a cool, dry place at 15-30°C in a tightly closed container, protected from light and humidity to maintain monohydrate stability. |
| Lead Time | 10 days |
Used as a second-generation BCR-ABL tyrosine kinase inhibitor intermediate in the synthesis of oral therapies for chronic myelogenous leukemia resistant to imatinib.