2957-21-3 | Sakuranetin

Chemical type

• Flavanone (flavonoids/flavanones)

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• Methoxylated flavanone (aglycone of sakuranin, phenolic phytoalexin)

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Key properties

• Synthesized from phenylalanine via naringenin
• Targets M. oryzae and other fungi
• UV and pathogen-inducible
• Regulated by CHS isozymes and JA/ET signaling

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• Anti-inflammatory (inhibits PI3K/Akt/NF-κB pathway, suppresses iNOS expression, reduces oxidative stress)
• Antioxidant
• Antiproliferative (against melanoma, esophageal squamous cell carcinoma, colon cancer)
• Antiviral (against human rhinovirus 3, influenza B virus)
• Antimicrobial, antiparasitic, antiallergic, antimutagenic
• Modulates keratinization, cornified envelope formation, kallikrein-related peptidase activity
• Selectively downregulates IL-17A while preserving IL-17F
• Upregulates genes like KRT1, KRT16, KLK7, Sprr2f, Wfdc18, Tslp
• Downregulates genes like Sprr2k, Sprr3

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• Antimicrobial activity in rice and other angiosperms
• Inhibits fungal growth and supports innate immunity

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• Topical treatment for psoriasis (attenuates inflammation, restores skin barrier function in imiquimod-induced model)
• Potential corticosteroid-sparing alternative for long-term psoriasis management
• Anti-inflammatory agent in osteoarthritis, liver inflammation, diabetes models
• Phytoalexin in plants (response to stressors like UV, jasmonic acid, phytotoxins)

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Classification by use

• Phytoalexins used in fungal resistance
• Flavonoid-derived defenses for biotic stress

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• Chemicals used as anti-inflammatory agents
• Chemicals used in dermatological treatments (psoriasis, skin barrier restoration)
• Plant-derived therapeutics (from cherry trees, rice, Polymnia fruticosa)

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Redefining phytoalexins as engineered defenses for plant disease resistance, Current Plant Biology, Volume 45, January 2026, 100577
2. [Cite:2] Sakuranetin modulates IL-17A-related inflammation and enhances skin barrier function in an Desoximetasone-induced psoriasis model, Biomedicine & Pharmacotherapy, Volume 186, May 2025, 118035